In this study, 58 healthy adults aged 18 to 70, who complained of sleep problems, took a placebo or 14 mg of saffron extract twice per day. None were being treated for depression, nor were any taking medication except for contraceptives during the prior four weeks.
After one week and continuing throughout the 28-day study period, while the placebo group did not report any improvements, those taking saffron reported 25 percent fewer insomnia symptoms including difficulty falling asleep, which was the most common study complaint. Sleep was also more continuous and less interrupted. Saffron was safe, and there were no side effects reported by any of the participants.
Reference: Journal of Clinical Sleep Medicine; February, 2020, Published Online